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Vibrating pill, ingestible sensor: mini robots tackle gut disorders

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Researchers at Caltech and MIT have developed an ingestible sensor that can be monitored as it moves through the digestive tract and tested it in pigs
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A pill that vibrates to relieve constipation, a sensor that can be tracked in the gut — medical researchers are turning to tiny robots to treat or diagnose gastrointestinal disorders.

“This is a very booming field,” said Saransh Sharma, a doctoral student at the California Institute of Technology (Caltech) involved in the development of the ingestible diagnostic sensor.

“You have medical robots that are so small you can just send them inside a person using the oral passage and they can do a lot of sensing and actuation inside the gut,” Sharma told AFP.

About 16 of every 100 adults in the United States suffer from symptoms of constipation, according to the US health authorities, and the number doubles for Americans over the age of 60.

Researchers at the Massachusetts Institute of Technology (MIT) and Caltech have developed an ingestible sensor that can be monitored as it travels through the digestive tract.

The device, 20 millimeters in length and eight mm in diameter, could help physicians diagnose gastrointestinal motility disorders that prevent food from moving normally through the digestive tract.

The capsule’s location reveals where a slowdown is taking place.

“That gives the doctor a lot of the essential information to do a better job in the curing and the diagnosis and the treatment plan,” Sharma said.

The sensor could also provide an alternative to invasive procedures such as endoscopy or other diagnostic techniques such as nuclear imaging, X-rays or catheters.

It has been tested on pigs and the team behind the research hopes to eventually obtain the approval of the US Food and Drug Administration for human clinical trials.

“If we can demonstrate a device inside large animals like pigs up to a very high confidence, we can say that it will scale very well in human anatomy as well,” Sharma said.

The authors published the results of their research on Monday in the journal Nature Electronics.

They said the sensor works by detecting a magnetic field produced by an electromagnetic coil located outside of the body.

The strength of the magnetic field varies with distance from the coil and the sensor’s position within the digestive tract can be calculated to within millimeters based on measurement of the magnetic field.

– Vibrating capsule –

While the ingestible sensor is still in the development phase, an Israeli company called Vibrant Gastro recently began marketing a vibrating capsule in the United States designed to relieve chronic constipation.

The drug-free Vibrant capsule is intended for constipation sufferers who have not received bowel relief after a month of laxative treatments. It has been FDA-approved.

In a Phase 3 clinical trial of 300 people, participants who took Vibrant had bowel movements significantly more frequently than those who took a placebo.

The Vibrant capsule produces gentle vibrations to stimulate the colon and increases the number and frequency of bowel movements, according to the manufacturer.

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In Brazil, hopes to use AI to save wildlife from roadkill fate

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Some 475 million vertebrate animals die on Brazilian roads every year
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In Brazil, where about 16 wild animals become roadkill every second, a computer scientist has come up with a futuristic solution to this everyday problem: using AI to alert drivers to their presence.

Direct strikes on the vast South American country’s extensive road network are the top threat to numerous species, forced to live in ever-closer proximity with humans.

According to the Brazilian Center for Road Ecology (CBEE), some 475 million vertebrate animals die on the road every year — mostly smaller species such as capybaras, armadillos and possums.

“It is the biggest direct impact on wildlife today in Brazil,” CBEE coordinator Alex Bager told AFP.

Shocked by the carnage in the world’s most biodiverse country, computer science student Gabriel Souto Ferrante sprung into action.

The 25-year-old started by identifying the five medium- and large-sized species most likely to fall victim to traffic accidents: the puma, the giant anteater, the tapir, the maned wolf and the jaguarundi, a type of wild cat.

Souto, who is pursuing a master’s degree at the University of Sao Paulo (USP), then created a database with thousands of images of these animals, and trained an AI model to recognize them in real time.

Numerous tests followed, and were successful, according to the results of his efforts recently published in the journal Scientific Reports.

Souto collaborated with the USP Institute of Mathematical and Computer Sciences.

For the project to become a reality, Souto said scientists would need “support from the companies that manage the roads,” including access to traffic cameras and “edge computing” devices — hardware that can relay a real-time warning to drivers like some navigation apps do.

There would also need to be input from the road concession companies, “to remove the animal or capture it,” he told AFP.

It is hoped the technology, by reducing wildlife strikes, will also save human lives.

– ‘More roads, more vehicles’- 

Bager said a variety of other strategies to stop the bloodshed on Brazilian roads have failed.

Signage warning drivers to be on the lookout for crossing animals have little influence, he told AFP, leading to a mere three-percent reduction in speed on average.

There are also so-called fauna bridges and tunnels meant to get animals safely from one side of the road to the other, and fences to keep them in — all insufficient to deal with the scope of the problem, according to Bager.

In 2014, he created an app called Urubu with other ecologists, to which thousands of users contributed information, allowing for the identification of roadkill hotspots.

The project helped to create public awareness and even inspired a bill on safe animal crossing and circulation, which is awaiting a vote in Congress. 

A lack of money saw the app being shut down last year, but Bager is intent on having it reactivated.

“We have more and more roads, more vehicles and a number of roadkill animals that likely continues to grow,” he said.

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Honda to build major EV plant in Canada: govt source

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Honda hopes to sell only zero-emission vehicles by 2040, with a goal of going carbon-neutral in its own operations by 2050
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Japanese auto giant Honda will open an electric vehicle plant in eastern Canada, a Canadian government source familiar with the multibillion-dollar project told AFP on Monday.

The federal government as well as the province of Ontario, where the plant will be built, will both provide some financial incentives for the deal, according to the source, who spoke on condition of anonymity.

The official announcement is due Thursday, though Ontario premier Doug Ford hinted at the deal on Monday.

“This week, we’ve landed a new deal. It will be the largest deal in Canadian history. It’ll be double the size of Volkswagen,” he said, referring to a battery plant announced last year, for which the German automaker pledged Can$7 billion (US$5 billion) in investment.

Canada in recent years has been positioning itself as an attractive destination for electric vehicle investment, touting tax incentives, renewable energy access and its rare mineral deposits.

The Honda plant, to be built an hour outside Toronto, in Alliston, will also produce electric-vehicle batteries, joining existing Volkswagen and Stellantis battery plants.

In January, when news of the deal first bubbled up in the Japanese press, the Nikkei newspaper estimated it would be worth Can$14 billion — numbers backed up by Canadian officials recently.

In the federal budget announced last week, Prime Minister Justin Trudeau’s government introduced a new business tax credit, granting companies a 10 percent rebate on construction costs for new buildings used in key segments of the electric vehicle supply chain.

Canada’s strategy follows that of the neighboring United States, whose Inflation Reduction Act has provided a host of incentives for green industry.

Honda hopes to sell only zero-emission vehicles by 2040, with a goal of going carbon-neutral in its own operations by 2050.

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Denmark launches its biggest offshore wind farm tender

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Denmark's offshore wind parks currently generate 2.7 gigawatts of electricity
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The Danish Energy Agency on Monday launched its biggest tender for the construction of offshore wind farms, aimed at producing six gigawatts by 2030 — more than double Denmark’s current capacity.

Offshore wind is one of the major sources of green energy that Europe is counting on to decarbonise electricity production and reach its 2050 target of net zero carbon production, but it remains far off the pace needed to hit its targets.

Denmark’s offshore wind parks currently generate 2.7 gigawatts of electricity, with another one GW due in 2027.

The tender covers six sites in four zones in Danish waters: North Sea I, Kattegat, Kriegers Flak II and Hesselo.

“We are pleased that we can now offer the largest offshore wind tender in Denmark to date. This is a massive investment in the green transition,”  Kristoffer Bottzauw, head of the Danish Energy Agency, said in a statement.

Investment in offshore wind plummeted in Europe in 2022 due to supply chain problems, high interest rates and a jump in prices of raw materials, before bouncing back in 2023.

A record 4.2 gigawatts was installed in Europe last year, when a record 30 billion euros in new projects were approved, the trade association WindEurope said in January.

It said it was optimistic about the future of offshore wind in Europe, expecting new offshore wind capacity of around five gigawatts per year for the next three years.

However, it noted that that was still far short of what is needed if Europe wants to hit its 2030 target of 111 gigawatts of offshore wind installed capacity, with less than 20 gigawatts installed at the end of 2023.

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