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Google AI tool predicts danger of genetic mutations

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Google's new AI tool can read DNA like a language, and see immediately if a word substitution will change the meaning of that sentence, the company says
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Researchers at Google DeepMind, the tech giant’s artificial intelligence arm, on Tuesday introduced a tool that predicts whether genetic mutations are likely to cause harm, a breakthrough that could help research into rare diseases.

The findings are “another step in recognising the impact that AI is having in the natural sciences,” said Pushmeet Kohli, vice president for research at Google DeepMind.

The tool focuses on so-called “missense” mutations, where a single letter of the genetic code is affected.

A typical human has 9,000 such mutations throughout their genome; they can be harmless or cause diseases such as cystic fibrosis or cancer, or damage brain development.

To date, four million of these mutations have been observed in humans, but only two percent of them have been classified, either as disease-causing or benign.

In all, there are 71 million such possible mutations. The Google DeepMind tool, called AlphaMissense, reviewed these mutations and was able to predict 89 percent of them, with 90 percent accuracy.

A score was assigned to each mutation, indicating the risk of it causing disease (otherwise referred to as pathogenic).

The result: 57 percent were classified as probably benign, and 32 percent as probably pathogenic — the remainder being uncertain.

The database was made public and available to scientists, and an accompanying study was published on Tuesday in the journal Science.

AlphaMissense demonstrates “superior performance” than previously available tools, wrote experts Joseph Marsh and Sarah Teichmann in an article also published in Science.

“We should emphasize that the predictions were never really trained or never really intended to be used for clinical diagnosis alone,” said Jun Cheng of Google DeepMind.

“However, we do think that our predictions can potentially be helpful to increase the diagnosed rate of rare disease, and also potentially to help us find new disease-causing genes,” Cheng added.

Indirectly, this could lead to the development of new treatments, the researchers said.

The tool was trained on the DNA of humans and closely-related primates, enabling it to recognize which genetic mutations are widespread.

Cheng said the training allowed the tool to input “millions of protein sequences and learns what a regular protein sequence looks like.”

It then could identify a mutation and its potential for harm.

Cheng compared the process to learning a language.

“If we substitute a word from an English sentence, a person that is familiar with English can immediately see whether this word substitution will change the meaning of the sentence or not.”

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TikTok reaches music licensing deal with Universal, ending feud

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The Universal-TikTok deal ends closely watched negotations that saw a breakdown earlier this year as two of the most powerful players in the music and tech industries publicly criticized each other as they jockeyed for leverage
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TikTok and Universal announced a new licensing agreement Thursday, ending a months-long dispute that saw popular music expunged from the social media platform.

The companies released a joint statement that said the new deal included “improved remuneration” for artists and songwriters under the Universal Music Group (UMG) umbrella, and will also assuage concerns over the growth of AI-generated content on TikTok.

Universal chairman Sir Lucian Grainge said “this new chapter in our relationship” would “drive innovation in fan engagement while advancing social music monetization.” 

The deal “focuses on the value of music, the primacy of human artistry and the welfare of the creative community,” he said.

TikTok’s CEO Shou Chew similarly said “we are committed to working together to drive value, discovery and promotion for all of UMG’s amazing artists and songwriters, and deepen their ability to grow, connect and engage with the TikTok community.”

The deal wraps up closely watched negotiations that saw a breakdown earlier this year, with the companies — two of the most powerful players in the music and tech industries — publicly criticizing each other as they jockeyed for leverage.

Universal — whose roster of artists includes Taylor Swift, Drake and Billie Eilish — ordered music from all artists connected to its vast publishing catalog to come down off the app, leaving many concerned over losing the marketing potential TikTok can offer.

Millions of videos involving Universal artists became muted on the platform.

But while the stripped music will now return to TikTok, it comes at a moment of uncertainty for the wildly popular video-sharing app, one week after a new US law demands the company divest from its Chinese parent company ByteDance or be shut out of the American market.

The app has 170 million users in the United States alone.

Neither Universal nor TikTok disclosed any financial terms of the deal.

Several weeks ago, the powerful and popular Swift returned some of her music to the app ahead of the release of her most recent album.

It was unclear exactly how she did it, but Swift does own her own master recordings as well as her songwriting rights, though those two are administered by Universal’s publishing arm.

In their joint statement the companies said they were “working expeditiously to return music by artists represented by Universal Music Group and songwriters represented by Universal Music Publishing Group to TikTok in due course.”

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Changpeng Zhao, the ‘normal guy’ who conquered crypto

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Changpeng Zhao pleaded guilty to violating US anti-money laundering laws and agreed to step down as Binance CEO
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During his time at the helm of the world’s biggest cryptocurrency firm, former Binance boss Changpeng Zhao, who will be sentenced in the United States later Tuesday for money laundering, perfected the humble executive look.

At parties, on stages and in meetings, he was rarely seen without his black polo shirt, emblazoned with the insignia of his firm — complemented by the corporate logo tattooed on his arm.

It was vital to cement the myth of a boy who came from hardship in China and once flipped burgers for a living in Canada — before making a fortune still estimated in the tens of billions.

“I’m a small entrepreneur,” and a “normal guy”, the man known in crypto circles as “CZ” told AFP in 2022 when comparing himself to Elon Musk, whose buyout of Twitter (now X) Zhao later backed with $500 million.

Yet there was little normal about Zhao’s leadership of Binance, a company that largely cornered the crypto-trading market before careening into a slew of charges including sanctions busting and illegal trading. 

Zhao, who founded Binance in Shanghai in 2017, emerged as the most visible figure in crypto after his great rival Sam Bankman-Fried was arrested in 2022 for masterminding a giant Ponzi scheme.

During his rival’s downfall, Zhao was there to twist the knife, first suggesting he might buy FTX before very publicly withdrawing.

A year later, it was Zhao’s turn for contrition.

He pleaded guilty to violating US anti-money laundering laws and agreed to step down as Binance CEO, the authorities announcing later that the firm would pay a $4.3 billion settlement.

– True grit? –

The legal cases painted a picture of Zhao as a ruthless operator pursuing growth at all costs.

It was a far cry from the folksy legend he had fostered, which had become almost mythical in crypto circles.

Zhao’s early life in China was scarred by hardship when his parents were sent to the countryside for a dose of peasant reality — a common punishment for those suspected of having capitalist sympathies during the Cultural Revolution of the 1960s and 1970s.

They emigrated to Canada in the late 1980s, where young Zhao worked at a McDonald’s and a petrol station to help the family survive, according to his own account of his life and a blog from 2020 on the Binance website.

This instilled “drive, grit, and initiative” into the young man and helped to create a “crypto leader”, the Binance blog said.

Zhao’s nomadic childhood informed his adult life, which has seen him crop up everywhere from New York to Tokyo.

The official legend has it that he caught the bitcoin bug during a conversation around a poker table in Shanghai in 2013, starting Binance in the Chinese city a few years later.

Beijing’s crackdown on crypto hastened his departure from China and he began his voyage through various jurisdictions, establishing a raft of complicated corporate structures on his way.

For years, he kept regulators at arm’s length by refusing to commit to a single jurisdiction for Binance’s headquarters, repeatedly saying it was a “complex issue”.

The stance made him a popular figure among crypto purists who loathe any form of regulation.

– ‘Good old times’ –

But the whiff of scandal finally got too strong for US market regulators, who labelled Binance’s compliance regime a “sham” and accused Zhao of orchestrating a “secret plot” to help VIP customers evade the law.

Then the law enforcement authorities came knocking.

Among other complaints, they accused Binance of failing to stop payments to the Islamic State militant group and other banned organisations in Iran and North Korea.

Unlike Bankman-Fried, Zhao was quick to admit guilt and avoid a high-profile trial.

But prosecutors are asking the court in Seattle to dole out a three-year prison sentence to Zhao.

In response to his troubles, Zhao has fallen back on his everyman persona.

He launched a start-up in March called the Giggle Academy that he said would aim to bring free education to underprivileged children around the world.

“Start up mode all over again. Like good old times,” he wrote on X in early April, just weeks before he was due to be sentenced.

Among the subjects he is aiming to teach? Blockchain, AI and finance.

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G7 to phase out coal-fired power plants by mid-2030s

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The mid-2030s phase out agreed by G7 ministers has been described as 'too late' by environmentalists
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G7 ministers agreed a timeframe Tuesday for phasing out coal-fired power plants, setting as a goal the mid-2030s, in a move hailed as significant by some environmentalists but slammed as “too late” by others.

The Group of Seven two-day meeting in Turin was the first big political session since the world pledged at the UN’s COP28 annual climate summit in Dubai in December to transition away from coal, oil and gas.

The G7 commits to “phase out existing unabated coal power generation in our energy systems during the first half of 2030s,” the final statement from energy and climate ministers read.

However it left some wiggle room, saying nations could follow “a timeline consistent with keeping a limit of 1.5-degrees-Celsius temperature rise within reach, in line with countries’ net zero pathways”.

It also preserved a place for coal power if it is “abated”, meaning its emissions are captured or limited by technology — something panned by many as unproven and a distraction from cutting fossil fuel use.

The G7 brings together Canada, France, Germany, Italy, Japan, the UK and US. 

Negotiations over a fixed date were reportedly tricky. Some countries, and many environmentalists, had been pushing for a 2030 limit, but Japan — which relies heavily on coal — was reluctant to set a date.

The leaders of the G7 countries will produce their own statement after a summit in southern Italy in June.

– ‘What about gas?’ –

The 2015 Paris Agreement saw countries agree to cap global warming at “well below” 2C above preindustrial times — with a safer limit of 1.5C if possible.

To keep the 1.5C limit in play, the UN’s climate expert panel has said emissions need to be slashed almost in half this decade, but they continue to rise.

The International Energy Agency (IEA) has said that to reach net zero emissions by 2050 — a key milestone to limit global warming — advanced economies should end all generation by unabated coal-fired power plants by 2030.

Italian Environment and Energy Security Minister Gilberto Pichetto Fratin said the talks had been “intense” but showed the G7 had “grasped” climate change.

Luca Bergamaschi from the Italian climate think tank ECCO said the G7 had taken a “decisive step forward” in translating the Dubai agreement into national policies.

The World Resources Institute hailed the commitment as “a beacon of hope for the rest of the world”.

But Oil Change International said the G7 “have failed” their first post-COP28 test, while the Climate Analytics policy institute said “2035 is too late”.

“Many of these countries have already publicly committed to phase out dates ahead of 2030, and only have a small amount of coal capacity anyway,” Jane Ellis from Climate Analytics said in a statement.

She also pointed out it was “notable that gas has not been mentioned”, despite it being the largest source of the global increase in CO2 emissions in the last decade.

Germany — Europe’s biggest emitter of greenhouse gases — is unwilling to wean off gas, as is G7 host Italy, which is investing in new domestic gas facilities.

– ‘Capable of contributing’ –

The G7 ministers did say they will scale-up battery storage “more than sixfold” by 2030, to support electricity grids powered by renewable energy sources.

They also tackled the thorny issue of plastic pollution amid a heated debate over how to best design a treaty addressing the scourge. 

Plastic waste is now found everywhere from the summits of mountains to the ocean floor and in human blood and breast milk. 

Broadly, the debate is between whether to focus on reducing production, or boosting recycling.

The ministers said they “aspired” to reduce and if necessary restrain the global production of plastic, and renewed their commitments to end plastic pollution by 2040.

Climate watchers are pushing for more funds for adaptation to climate change and energy systems for developing countries, and all eyes will be on the G7 finance minister’s meeting in at the end of May.

The ministers in Turin stressed efforts to raise money to help poorer countries deal with climate change should include “those countries that are capable of contributing”.

Under a UN climate treaty signed in 1992, only a small handful of high-income countries that dominated the global economy at the time were required to pay climate finance — not including China, which has since become wealthier, and is now the world’s largest polluter.

“By making it clear that we were calling on other countries to contribute, we want China to join us in this direction,” Franck Riester, the minister representing France on climate issues, told AFP.

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